Collaborators. GG. Global, regional, and national burden of gout, 1990–2020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021. Lancet Rheumatol. 2024;6:e507–e517.
Google Scholar
Yanai H, Adachi H, Hakoshima M, Katsuyama H. Molecular biological and clinical understanding of the pathophysiology and treatments of hyperuricemia and its association with metabolic syndrome, cardiovascular diseases and chronic kidney disease. Int J Mol Sci. 2021;22:9221.
Mei Y, Dong B, Geng Z, Xu L. Excess uric acid induces gouty nephropathy through crystal formation: a review of recent insights. Front Endocrinol. 2022;13:911968.
Google Scholar
Dehlin M, Jacobsson L, Roddy E. Global epidemiology of gout: prevalence, incidence, treatment patterns and risk factors. Nat Rev Rheumatol. 2020;16:380–90.
Google Scholar
Han T, Chen W, Qiu X, Wang W. Epidemiology of gout – Global burden of disease research from 1990 to 2019 and future trend predictions. Ther Adv Endocrinol Metab. 2024;15:20420188241227295.
Google Scholar
He Q, Mok TN, Sin TH, Yin J, Li S, Yin Y, et al. Global, regional, and national prevalence of gout from 1990 to 2019: age-period-cohort analysis with future burden prediction. JMIR Public Health Surveill. 2023;9:e45943.
Google Scholar
Topless RKG, Major TJ, Florez JC, Hirschhorn JN, Cadzow M, Dalbeth N, et al. The comparative effect of exposure to various risk factors on the risk of hyperuricaemia: diet has a weak causal effect. Arthritis Res Ther. 2021;23:75.
Google Scholar
Chi X, Zhang H, Zhang S, Ma K. Chinese herbal medicine for gout: a review of the clinical evidence and pharmacological mechanisms. Chin Med. 2020;15:17.
Google Scholar
Liang H, Deng P, Ma YF, Wu Y, Ma ZH, Zhang W, et al. Advances in experimental and clinical research of the gouty arthritis treatment with Traditional Chinese Medicine. Evid Based Complement Altern Med. 2021;2021:8698232.
Google Scholar
Yokose C, Mccormick N, Lu N, Joshi AD, Curhan G, Choi HK. Adherence to 2020 to 2025 dietary guidelines for Americans and the risk of new-onset female gout. JAMA Intern Med. 2022;182:254–64.
Google Scholar
Seifi N, Bahari H, Nosrati M, Koochakpoor G, Alizadeh Hassani Z, Rastegarmoghadam-Ebrahimian A, et al. Higher dietary acid load is associated with the risk of hyperuricemia. Int Urol Nephrol. 2024;56:1743–9.
Google Scholar
Krata AA, Domagala J, Glowacki R. Hydrophilic interaction liquid chromatography based method for simultaneous determination of purines and their derivatives in food spices. Food Chem. 2024;441:138285.
Google Scholar
Choi HK, Atkinson K, Karlson EW, Willett W, Curhan G. Purine-rich foods, dairy and protein intake, and the risk of gout in men. N Engl J Med. 2004;350:1093–103.
Google Scholar
Dong YF, Sun N, Ge Q, Lv RZ, Lin SY. Antioxidant soy peptide can inhibit xanthine oxidase activity and improve LO2 cell damage. Food Biosci. 2023;52:102455.
Zhang C, Li L, Zhang Y, Zeng C. Recent advances in fructose intake and risk of hyperuricemia. Biomed Pharmacother. 2020;131:110795.
Google Scholar
Helget LN, Mikuls TR. Environmental triggers of hyperuricemia and gout. Rheum Dis Clin North Am. 2022;48:891–906.
Google Scholar
Zhan X, He M, Pei J, Fan W, Mwangi CN, Zhang P, et al. Natural phenylethanoid supplementation alleviates metabolic syndrome in female mice induced by high-fructose diet. Front Pharmacol. 2022;13:850777.
Google Scholar
Chen Y, Liu Q, Meng X, Zhao L, Zheng X, Feng W. Catalpol ameliorates fructose-induced renal inflammation by inhibiting TLR4/MyD88 signaling and uric acid reabsorption. Eur J Pharmacol. 2024;967:176356.
Google Scholar
Yang Y, Zheng S, Feng Y. Associations between vitamin C intake and serum uric acid in US adults: findings from national health and nutrition examination survey 2011–2016. PLoS One. 2023;18:e0287352.
Google Scholar
Bang M, Heo Y, Choi TK, Lee SH. Positive effects of uric acid on white matter microstructures and treatment response in patients with schizophrenia. Schizophr Bull. 2024;50:815–26.
Google Scholar
Sandoval-Plata G, Nakafero G, Chakravorty M, Morgan K, Abhishek A. Association between serum urate, gout and comorbidities: a case-control study using data from the UK Biobank. Rheumatology. 2021;60:3243–51.
Google Scholar
Liu S, Sun H, Yang S, Liang N, Gao Y, Qu S, et al. Clustering of gout-related comorbidities and their relationship with gout flares: a data-driven cluster analysis of eight comorbidities. J Endocrinol Invest. 2024;47:1119–28.
Google Scholar
Yokose C, Mccormick N, Abhishek A, Dalbeth N, Pascart T, Liote F, et al. The clinical benefits of sodium-glucose cotransporter type 2 inhibitors in people with gout. Nat Rev Rheumatol. 2024;20:216–31.
Google Scholar
Macay AL, Flores KM, Fernández-Torres J, Zamudio Y, Muñoz FS, Clavijo-Cornejo D. Gene expression of Abcg2, Alpk1, Slc22a12 and Il-1β in peripheral blood leukocytes of gout patients were correlated with their comorbidities and hyperuricemia. Ann Rheum Dis. 2023;82:1191–2.
Xu Z, Tao L, Su H. The complement system in metabolic-associated kidney diseases. Front Immunol. 2022;13:902063.
Google Scholar
Gherghina ME, Peride I, Tiglis M, Neagu TP, Niculae A, Checherita IA. Uric acid and oxidative stress-relationship with cardiovascular, metabolic, and renal impairment. Int J Mol Sci. 2022;23:3188.
Liang N, Wu M, Gao Y, Yang S, Lin X, Sun H, et al. Purine metabolic pathway alterations and serum urate changes after oral inosine loading in male Chinese volunteers. Mol Nutr Food Res. 2024;68:e2300115.
Google Scholar
Pang L, Liang N, Li C, Merriman TR, Zhang H, Yan F, et al. A stable liver-specific urate oxidase gene knockout hyperuricemia mouse model finds activated hepatic de novo purine biosynthesis and urate nephropathy. Biochim Biophys Acta Mol Basis Dis. 2024;1870:167009.
Google Scholar
Lopez JM, Outtrim EL, Fu R, Sutcliffe DJ, Torres RJ, Jinnah HA. Physiological levels of folic acid reveal purine alterations in Lesch-Nyhan disease. Proc Natl Acad Sci USA. 2020;117:12071–9.
Google Scholar
Gulati HK, Khanna A, Kumar N, Sharma A, Rupali, Jyoti, et al. Triazole derivatives as potential xanthine oxidase inhibitors: design, enzyme inhibition potential, and docking studies. Arch Pharmacol. 2024;357:e2300296.
Google Scholar
Xie H, Hu N, Pan T, Wu JC, Yu M, Wang DC. Effectiveness and safety of different doses of febuxostat compared with allopurinol in the treatment of hyperuricemia: a meta-analysis of randomized controlled trials. BMC Pharmacol Toxicol. 2023;24:79.
Google Scholar
Xing Z, Zhang F, Gao M, Xu Z, Liu Y, Shen G. Effect and mechanism of Rhein-praseodymium complex on intestinal uric acid excretion in rats with renal injury and hyperuricemia. Curr Med Chem. 2024. https://doi.org/10.2174/0109298673268642231214061615.
Yin H, Liu N, Chen J. The role of the intestine in the development of hyperuricemia. Front Immunol. 2022;13:845684.
Google Scholar
Mandal AK, Mount DB. The molecular physiology of uric acid homeostasis. Annu Rev Physiol. 2015;77:323–45.
Google Scholar
Li L, Zhang Y, Zeng C. Update on the epidemiology, genetics, and therapeutic options of hyperuricemia. Am J Transl Res. 2020;12:3167–81.
Google Scholar
Yang B, Xin M, Liang S, Xu X, Cai T, Dong L, et al. New insight into the management of renal excretion and hyperuricemia: potential therapeutic strategies with natural bioactive compounds. Front Pharmacol. 2022;13:1026246.
Google Scholar
Halperin Kuhns VL, Woodward OM. Urate transport in health and disease. Best Pr Res Clin Rheumatol. 2021;35:101717.
Google Scholar
Ohashi Y, Kuriyama S, Nakano T, Sekine M, Toyoda Y, Nakayama A, et al. Urate transporter ABCG2 function and asymptomatic hyperuricemia: a retrospective cohort study of CKD progression. Am J Kidney Dis. 2023;81:134–44.
Google Scholar
Sun HL, Bian HG, Liu XM, Zhang H, Ying J, Yang H, et al. GRP/GRPR signaling pathway aggravates hyperuricemia-induced renal inflammation and fibrosis via ABCG2-dependent mechanisms. Biochem Pharmacol. 2023;218:115901.
Google Scholar
Zhao T, Cao L, Lin C, Xu R, Du X, Zhou M, et al. Intestinal uric acid excretion contributes to serum uric acid decrease during acute gout attack. Rheumatology. 2023;62:3984–92.
Google Scholar
Chiba T, Matsuo H, Kawamura Y, Nagamori S, Nishiyama T, Wei L, et al. NPT1/SLC17A1 is a renal urate exporter in humans and its common gain-of-function variant decreases the risk of renal underexcretion gout. Arthritis Rheumatol. 2015;67:281–7.
Google Scholar
Zhang J, Wang H, Fan Y, Yu Z, You G. Regulation of organic anion transporters: role in physiology, pathophysiology, and drug elimination. Pharmacol Ther. 2021;217:107647.
Google Scholar
Li L, Zhao K, Luo J, Tian J, Zheng F, Lin X, et al. Piperine improves hyperuricemic nephropathy by inhibiting URAT1/GLUT9 and the AKT-mTOR pathway. J Agric Food Chem. 2024;72:6565–74.
Google Scholar
Li X, Qi C, Shao M, Yang Y, Wang Y, Li J, et al. A system for discovering novel uricosurics targeting urate transporter 1 based on in vitro and In vivo modeling. Pharmaceutics. 2024;16:172.
Perez-Ruiz F, Sundy JS, Miner JN, Cravets M, Storgard C, Group RS. Lesinurad in combination with allopurinol: results of a phase 2, randomised, double-blind study in patients with gout with an inadequate response to allopurinol. Ann Rheum Dis. 2016;75:1074–80.
Google Scholar
Yan F, Xue X, Lu J, Dalbeth N, Qi H, Yu Q, et al. Superiority of low-dose benzbromarone to low-dose febuxostat in a prospective, randomized comparative effectiveness trial in gout patients with renal uric acid underexcretion. Arthritis Rheumatol. 2022;74:2015–23.
Google Scholar
Ferreira JP, Zannad F, Kiernan MS, Konstam MA. High- versus low-dose losartan and uric acid: an analysis from HEAAL. J Cardiol. 2023;82:57–61.
Google Scholar
Keenan RT, Botson JK, Masri KR, Padnick-Silver L, Lamoreaux B, Albert JA, et al. The effect of immunomodulators on the efficacy and tolerability of pegloticase: a systematic review. Semin Arthritis Rheum. 2021;51:347–52.
Google Scholar
Herrero-Goni M, Zugazabeitia Irazabal A, Madariaga L, Chavarri Gil E, Gondra L, Aguirre Menica M. Use of rasburicase to improve kidney function in children with hyperuricemia and acute kidney injury. Clin Exp Nephrol. 2024;28:13–22.
Google Scholar
Pu MJ, Yao CJ, Liu LM, Ren LJ, Li YL, Xie Y. Traditional Chinese medicine for gouty arthritis: a protocol for meta-analysis. Medicine. 2021;100:e23699.
Google Scholar
Zhou H, Yang J, Yuan X, Song X, Zhang X, Cao T, et al. Hyperuricemia research progress in model construction and traditional Chinese medicine interventions. Front Pharmacol. 2024;15:1294755.
Google Scholar
Liu ZQ, Sun X, Liu ZB, Zhang T, Zhang LL, Wu CJ. Phytochemicals in traditional Chinese medicine can treat gout by regulating intestinal flora through inactivating NLRP3 and inhibiting XOD activity. J Pharm Pharm. 2022;74:919–29.
Google Scholar
Xu GT, Wu LL, Yang HX, Liu TF, Tong Y, Wan JL, et al. Eupatilin inhibits xanthine oxidase in vitro and attenuates hyperuricemia and renal injury in vivo. Food Chem Toxicol. 2024;183:114307.
Zhao Z, Luo J, Liao H, Zheng F, Chen X, Luo J, et al. Pharmacological evaluation of a novel skeleton compound isobavachin (4’,7-dihydroxy-8-prenylflavanone) as a hypouricemic agent: dual actions of URAT1/GLUT9 and xanthine oxidase inhibitory activity. Bioorg Chem. 2023;133:106405.
Google Scholar
Huang X, Dong W, Luo X, Xu L, Wang Y. Target screen of anti-hyperuricemia compounds from Cortex Fraxini in vivo based on ABCG2 and bioaffinity ultrafiltration mass spectrometry. Molecules. 2023;28:7896.
An MF, Shen C, Zhang SS, Wang MY, Sun ZR, Fan MS, et al. Anti-hyperuricemia effect of hesperetin is mediated by inhibiting the activity of xanthine oxidase and promoting excretion of uric acid. Front Pharmacol. 2023;14:1128699.
Google Scholar
Desai J, Steiger S, Anders HJ. Molecular pathophysiology of gout. Trends Mol Med. 2017;23:756–68.
Google Scholar
Li D, Yuan S, Deng Y, Wang X, Wu S, Chen X, et al. The dysregulation of immune cells induced by uric acid: mechanisms of inflammation associated with hyperuricemia and its complications. Front Immunol. 2023;14:1282890.
Google Scholar
Lopez-Reyes A, Medina-Luna D, Santamaria-Olmedo M, Martinez-Flores K, Zamudio-Cuevas Y, Fernandez-Torres J, et al. Soluble inflammatory mediators of synoviocytes stimulated by monosodium urate crystals induce the production of oxidative stress, pain, and inflammation mediators in chondrocytes: Secretome of synoviocytes induces chondrocyte damage. Clin Rheumatol. 2021;40:3265–71.
Google Scholar
Klück V, Liu R, Joosten LAB. The role of interleukin-1 family members in hyperuricemia and gout. Jt Bone Spine. 2021;88:105092.
Google Scholar
Garcia-Gonzalez E, Gamberucci A, Lucherini OM, Ali A, Simpatico A, Lorenzini S, et al. Neutrophil extracellular traps release in gout and pseudogout depends on the number of crystals regardless of leukocyte count. Rheumatology. 2021;60:4920–8.
Google Scholar
Tao H, Mo Y, Liu W, Wang H. A review on gout: looking back and looking ahead. Int Immunopharmacol. 2023;117:109977.
Google Scholar
Koncz G, Jenei V, Toth M, Varadi E, Kardos B, Bacsi A, et al. Damage-mediated macrophage polarization in sterile inflammation. Front Immunol. 2023;14:1169560.
Google Scholar
Wang Y, Xu Y, Tan J, Ye J, Cui W, Hou J, et al. Anti-inflammation is an important way that Qingre-Huazhuo-Jiangsuan recipe treats acute gouty arthritis. Front Pharmacol. 2023;14:1268641.
Google Scholar
Zhou M, Hua L, Wang YF, Chen ST, Yang CM, Zhang M, et al. Oral Huzhang granules for the treatment of acute gouty arthritis: protocol for a double-blind, randomized, controlled trial. Trials. 2022;23:248.
Google Scholar
Xu H, Chen J, Chen P, Li W, Shao J, Hong S, et al. Costunolide covalently targets NACHT domain of NLRP3 to inhibit inflammasome activation and alleviate NLRP3-driven inflammatory diseases. Acta Pharm Sin B. 2023;13:678–93.
Google Scholar
He H, Jiang H, Chen Y, Ye J, Wang A, Wang C, et al. Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity. Nat Commun. 2018;9:2550.
Google Scholar
Li W, Xu H, Shao J, Chen J, Lin Y, Zheng Z, et al. Discovery of alantolactone as a naturally occurring NLRP3 inhibitor to alleviate NLRP3-driven inflammatory diseases in mice. Br J Pharmacol. 2023;180:1634–47.
Google Scholar
Cabau G, Crisan TO, Kluck V, Popp RA, Joosten LAB. Urate-induced immune programming: consequences for gouty arthritis and hyperuricemia. Immunol Rev. 2020;294:92–105.
Google Scholar
Zhang H, Ma Y, Cao R, Wang G, Li S, Cao Y, et al. Soluble uric acid induces myocardial damage through activating the NLRP3 inflammasome. J Cell Mol Med. 2020;24:8849–61.
Google Scholar
So AK, Martinon F. Inflammation in gout: mechanisms and therapeutic targets. Nat Rev Rheumatol. 2017;13:639–47.
Google Scholar
Ai G, Huang R, Xie J, Zhong L, Wu X, Qin Z, et al. Hypouricemic and nephroprotective effects of palmatine from Cortex Phellodendri Amurensis: a uric acid modulator targeting Keap1-Nrf2/NLRP3 axis. J Ethnopharmacol. 2023;301:115775.
Google Scholar
Qadri M, Khired Z, Alaqi R, Elsayed S, Alarifi A, Ahmed R, et al. Zerumbone reduces TLR2 stimulation-induced M1 macrophage polarization pattern via upregulation of Nrf-2 expression in murine macrophages. Saudi Pharmacol J. 2024;32:101956.
Google Scholar
Lin Y, Luo T, Weng A, Huang X, Yao Y, Fu Z, et al. Gallic acid alleviates gouty arthritis by inhibiting NLRP3 inflammasome activation and pyroptosis through enhancing Nrf2 signaling. Front Immunol. 2020;11:580593.
Google Scholar
Casado-Barragan F, Lazcano-Paez G, Larenas PE, Aguirre-Delgadillo M, Olivares-Aravena F, Witto-Oyarce D, et al. Increased renal medullary NOX-4 in female but not male mice during the early phase of type 1 diabetes: potential role of ROS in upregulation of TGF-beta1 and fibronectin in collecting duct cells. Antioxidants (Basel). 2023;12:729.
Chen JH, Wu PT, Chyau CC, Wu PH, Lin HH. The nephroprotective effects of Hibiscus sabdariffa leaf and ellagic acid in vitro and in vivo models of hyperuricemic nephropathy. J Agric Food Chem. 2023;71:382–97.
Google Scholar
Wang S, Fang Y, Yu X, Guo L, Zhang X, Xia D. The flavonoid-rich fraction from rhizomes of Smilax glabra Roxb. ameliorates renal oxidative stress and inflammation in uric acid nephropathy rats through promoting uric acid excretion. Biomed Pharmacother. 2019;111:162–8.
Google Scholar
Liu C, Zhou HN, Zhang RR, Wang XK, He SW, Zhang JB, et al. Anti-hyperuricemic and nephroprotective effect of geniposide in chronic hyperuricemia mice. J Funct Foods. 2019;61:103355.
Feng W, Zhong XQ, Zheng XX, Liu QP, Liu MY, Liu XB, et al. Study on the effect and mechanism of quercetin in treating gout arthritis. Int Immunopharmacol. 2022;111:109112.
Google Scholar
Zarneshan SN, Fakhri S, Farzaei MH, Khan H, Saso L. Astaxanthin targets PI3K/Akt signaling pathway toward potential therapeutic applications. Food Chem Toxicol. 2020;145:111714.
Google Scholar
Lu H, Yao H, Zou R, Chen X, Xu H. Galangin suppresses renal inflammation via the inhibition of NF-kappaB, PI3K/AKT and NLRP3 in uric Acid treated NRK-52E tubular epithelial cells. Biomed Res Int. 2019;2019:3018357.
Google Scholar
Liu Y, Gong S, Li K, Wu G, Zheng X, Zheng J, et al. Coptisine protects against hyperuricemic nephropathy through alleviating inflammation, oxidative stress and mitochondrial apoptosis via PI3K/Akt signaling pathway. Biomed Pharmacother. 2022;156:113941.
Google Scholar
Yang B, Xin M, Liang S, Huang Y, Li J, Wang C, et al. Naringenin ameliorates hyperuricemia by regulating renal uric acid excretion via the PI3K/AKT signaling pathway and renal inflammation through the NF-kappaB signaling pathway. J Agric Food Chem. 2023;71:1434–46.
Google Scholar
Zhou Q, Lin FF, Liu SM, Sui XF. Influence of the total saponin fraction from Dioscorea nipponica Makino on TLR2/4-IL1R receptor singnal pathway in rats of gouty arthritis. J Ethnopharmacol. 2017;206:274–82.
Google Scholar
Lee SJ, Nam KI, Jin HM, Cho YN, Lee SE, Kim TJ, et al. Bone destruction by receptor activator of nuclear factor kappaB ligand-expressing T cells in chronic gouty arthritis. Arthritis Res Ther. 2011;13:R164.
Google Scholar
Wang X, Sheng Y, Guan J, Zhang F, Lou C. Sanmiao wan alleviates inflammation and exhibits hypouricemic effect in an acute gouty arthritis rat model. J Ethnopharmacol. 2024;324:117764.
Google Scholar
Shi L, Zhao F, Zhu F, Liang Y, Yang F, Zhang G, et al. Traditional Chinese Medicine Formula “Xiaofeng granules” suppressed gouty arthritis animal models and inhibited the proteoglycan degradation on chondrocytes induced by monosodium urate. J Ethnopharmacol. 2016;191:254–63.
Google Scholar
Zhu F, Yin L, Ji L, Yang F, Zhang G, Shi L, et al. Suppressive effect of Sanmiao formula on experimental gouty arthritis by inhibiting cartilage matrix degradation: an in vivo and in vitro study. Int Immunopharmacol. 2016;30:36–42.
Google Scholar
Hwang SH, Kim SB, Jang SP, Wang Z, Suh HW, Lim SS. Anti-nociceptive effect and standardization from mixture of Agrimonia pilosa Ledeb and Salvia miltiorrhiza Bunge extracts. J Med Food. 2018;21:596–604.
Google Scholar
Kim HY, Zuo GL, Lee HJ, Hwang SH, Lee SK, Park JH, et al. Evaluation of the antinociceptive effect and standardization of Platycladus orientalis (L.) Franco extract. Mol Cell Toxicol. 2024;20:747–57.
Google Scholar
Cao W, Xu DL, Wu WH, Xu T, Li TJ. Experimental study on anti-inflammation and analgesic effects of extracts of compound Shuiniujiao. Pharmacol Care Res. 2011;11:103–6.
Google Scholar
Miao L, Yuan Z, Zhang S, Zhang G. Honokiol alleviates monosodium urate-induced gouty pain by inhibiting voltage-gated proton channels in mice. Inflammopharmacology. 2024;32:2413–25.
Google Scholar
Zhou E, Shen Q, Hou Y. Integrating artificial intelligence into the modernization of traditional Chinese medicine industry: a review. Front Pharmacol. 2024;15:1181183.
Google Scholar
Song Z, Chen G, Chen CY. AI empowering traditional Chinese medicine? Chem Sci. 2024;15:16844–86.
Google Scholar
Lu M, Yin J, Xu T, Dai X, Liu T, Zhang Y, et al. Fuling-Zexie formula attenuates hyperuricemia-induced nephropathy and inhibits JAK2/STAT3 signaling and NLRP3 inflammasome activation in mice. J Ethnopharmacol. 2024;319:117262.
Google Scholar
Hsieh CY, Tsai PW, Tomioka Y, Matsumoto Y, Akiyama Y, Wang CC, et al. Chronopharmacology of diuresis via metabolic profiling and key biomarker discovery of the traditional Chinese prescription Ji-Ming-San using tandem mass spectrometry in rat models. Phytomedicine. 2024;124:155260.
Google Scholar
Meng J, Tian J, Zhao Y, Li C, Yi Y, Zhang Y, et al. Ameliorative effect of cheqianzi decoction on hyperuricemia and kidney injury and underlying mechanism in rats. Heliyon. 2023;9:e15333.
Google Scholar
Song S, Fan M, Wen X, Shi X, Lou Y, He Z, et al. Integrated network pharmacology and gut microbiome analysis to reveal the mechanism of Qu-Zhuo-Tong-Bi decoction against hyperuricemia and gout. J Ethnopharmacol. 2023;316:116736.
Google Scholar
Huang Z, Zhang W, An Q, Lang Y, Liu Y, Fan H, et al. Exploration of the anti-hyperuricemia effect of TongFengTangSan (TFTS) by UPLC-Q-TOF/MS-based non-targeted metabonomics. Chin Med. 2023;18:17.
Google Scholar
Lin X, Shao T, Huang L, Wen X, Wang M, Wen C, et al. Simiao Decoction alleviates gouty arthritis by modulating proinflammatory cytokines and the gut ecosystem. Front Pharmacol. 2020;11:955.
Google Scholar
Shui G, Cai Z, Wang F, Chen T, Huang X, Cai Y, et al. Simiao pill inhibits epithelial mesenchymal transition in a mouse model of chronic hyperuricemic nephropathy by inhibiting NLRP3 inflammasome activation. BMC Complement Med Ther. 2022;22:278.
Google Scholar
Huang J, Lin Z, Wang Y, Ding X, Zhang B. Wuling San based on network pharmacology and in vivo evidence against hyperuricemia via improving oxidative stress and inhibiting inflammation. Drug Des Devel Ther. 2023;17:675–90.
Google Scholar
Xi S, Zhiguoshao, Li L, Gui Z, Liu P, Jiang Q, et al. Tongbixiao Pills improve gout by reducing uric acid levels and inhibiting inflammation. Dose Response. 2022;20:15593258221090340.
Google Scholar
Li MH, Guan J, Chen Z, Mo JX, Wu KR, Hu XG, et al. Fufang Zhenzhu Tiaozhi capsule ameliorates hyperuricemic nephropathy by inhibition of PI3K/AKT/NF-kappaB pathway. J Ethnopharmacol. 2022;298:115644.
Google Scholar
Qin Y, Zhang X, Tao H, Wu Y, Yan J, Liao L, et al. Ameliorative effect and mechanism of Yi-Suan-Cha against hyperuricemia in rats. J Clin Lab Anal. 2021;35:e23859.
Google Scholar
Huang B, Hu X, Wang J, Li P, Chen J. Study on chemical constituents of herbal formula Er Miao Wan and GC-MS based metabolomics approach to evaluate its therapeutic effects on hyperuricemic rats. J Chromatogr B Anal Technol Biomed Life Sci. 2019;1118-1119:101–8.
Google Scholar
Gao Y, Sun J, Zhang Y, Shao T, Li H, Wang M, et al. Effect of a Traditional Chinese Medicine formula (CoTOL) on serum uric acid and intestinal flora in obese hyperuricemic mice inoculated with intestinal bacteria. Evid Based Complement Altern Med. 2020;2020:8831937.
Google Scholar
Yang A, Guo H, Fu M, Liu M. Inhibitive effects of Huashi Pill on formation of renal stones by modulating urine biochemical indexes and osteopontin in renal stone rat models. Med Sci Monit. 2019;25:8335–44.
Google Scholar
Liu YW, Sun WF, Zhang XX, Li J, Zhang HH. Compound Tufuling Granules ([characters: see text]) regulate glucose transporter 9 expression in kidney to influence serum uric acid level in hyperuricemia mice. Chin J Integr Med. 2015;21:823–9.
Google Scholar
Wu P, Li J, Zhang X, Zeng F, Liu Y, Sun W. Study of the treatment effects of compound Tufuling Granules in hyperuricemic rats using serum metabolomics. Evid Based Complement Altern Med. 2018;2018:3458185.
Google Scholar
Wu Y, He F, Li Y, Wang H, Shi L, Wan Q, et al. Effects of Shizhifang on NLRP3 inflammasome activation and renal tubular injury in hyperuricemic rats. Evid Based Complement Altern Med. 2017;2017:7674240.
Google Scholar
Wu Y, Wang Y, Ou J, Wan Q, Shi L, Li Y, et al. Effect and mechanism of ShiZhiFang on uric acid metabolism in hyperuricemic rats. Evid Based Complement Altern Med. 2018;2018:6821387.
Google Scholar
Zuo J, He H, Zuo Z, Bou-Chacra N, Lobenberg R. Erding Formula in hyperuricaemia treatment: unfolding traditional Chinese herbal compatibility using modern pharmaceutical approaches. J Pharm Pharmacol. 2018;70:124–32.
Google Scholar
Huijuan W, Xiaoxu C, Rui S, Xinghui L, Beibei T, Jianchun M. Qi-Zhu-Xie-Zhuo-Fang reduces serum uric acid levels and ameliorates renal fibrosis in hyperuricemic nephropathy rats. Biomed Pharmacother. 2017;91:358–65.
Google Scholar
Wang XY, Zhou JB, Shi B, Guo XL, Yan QC. Hypouricemic and nephroprotective effects of Jianpi Huashi decoction in a rat model of hyperuricemia. Int J Clin Exp Med. 2016;9:455–65.
Google Scholar
Wang R, Ma CH, Zhou F, Kong LD. Siwu decoction attenuates oxonate-induced hyperuricemia and kidney inflammation in mice. Chin J Nat Med. 2016;14:499–507.
Google Scholar
Amat N, Umar A, Hoxur P, Anaydulla M, Imam G, Aziz R, et al. Traditional Uighur Medicine Karapxa decoction, inhibits liver xanthine oxidase and reduces serum uric acid concentrations in hyperuricemic mice and scavenges free radicals in vitro. BMC Complement Alter Med. 2015;15:131.
Google Scholar
Sun WF, Zhu MM, Li J, Zhang XX, Liu YW, Wu XR, et al. Effects of Xie-Zhuo-Chu-Bi-Fang on miR-34a and URAT1 and their relationship in hyperuricemic mice. J Ethnopharmacol. 2015;161:163–9.
Google Scholar
Chen Y, Lu Y, Wang YN, Lin ZC, Gu W, Tan L, et al. Effect of compound qingqin liquid on the expression of toll-like receptor in the renal tissue of rats with urate nephropathy. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2014;34:722–7. Chinese.
Google Scholar
Shang XZ, Ma WG, Chen Y, Lu Y, Wang YN, Xu YM, et al. Effect of compound qingqin liquid on the expression levels of ang II and COX-2 mRNA transcription and protein expression in the renal tissue of uric acid nephropathy rats: an experimental study. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2014;34:819–25. Chinese.
Google Scholar
Pan Y, Chu Z, Wang W, Yang B. Pretreatment with Jieduxiezhuo decoction impedes elevations in serum uric acid levels in mice. J Tradit Chin Med. 2013;33:794–7.
Google Scholar
Yang H, Su J, Jiang G, Chen X. Effect of Tongxi Powder on blood uric acid of mice with acute hyperuricemia. Chin Tradit Herb Drugs. 2013;44:1635–7.
Google Scholar
Li Y, Wei Y, Han X. Effects of Danggui Buxue Tang on heart muscle function in hyperuricemic rats. Chin Pharm J. 2010;45:524–6.
Google Scholar
Yu XN, Wu HY, Deng YP, Zhuang GT, Tan BH, Huang YZ, et al. “Yellow-dragon Wonderful-seed Formula” for hyperuricemia in gout patients with dampness-heat pouring downward pattern: a pilot randomized controlled trial. Trials. 2018;19:551.
Google Scholar
Wang Y, Wang L, Li E, Li Y, Wang Z, Sun X, et al. Chuanhu anti-gout mixture versus colchicine for acute gouty arthritis: a randomized, double-blind, double-dummy, non-inferiority trial. Int J Med Sci. 2014;11:880–5.
Google Scholar
Yao J, Bai E, Duan Y, Huang Y. Ethanol extracts from Torreya grandis seed have potential to reduce hyperuricemia in mouse models by influencing purine metabolism. Foods. 2024;13:840.
Zhang T, Liu L, Chen Q, Wang Y, Gao X, Ma X, et al. Comparative assessment of in vitro xanthine oxidase and alpha-glucosidase inhibitory activities of cultured cambial meristematic cells, adventitious roots, and field-cultivated Ginseng. Nutrients. 2024;16:443.
Du J, Wang N, Yu D, He P, Gao Y, Tu Y, et al. Data mining-guided alleviation of hyperuricemia by Paeonia veitchii Lynch through inhibition of xanthine oxidase and regulation of renal urate transporters. Phytomedicine. 2024;124:155305.
Google Scholar
Xu R, Deng P, Ma Y, Li K, Ren F, Li N. Anti-hyperuricemic effects of extracts from Chaenomeles speciosa (Sweet) Nakai fruits on hyperuricemic rats. Metabolites. 2024;14:117.
Zhang MQ, Sun KX, Guo X, Chen YY, Feng CY, Chen JS, et al. The antihyperuricemia activity of Astragali Radix through regulating the expression of uric acid transporters via PI3K/Akt signalling pathway. J Ethnopharmacol. 2023;317:116770.
Google Scholar
Zhu C, Niu H, Bian M, Zhang X, Zhang X, Zhou Z. Study on the mechanism of Orthosiphon aristatus (Blume) Miq. in the treatment of hyperuricemia by microbiome combined with metabonomics. J Ethnopharmacol. 2023;317:116805.
Google Scholar
Ma N, Cai S, Sun Y, Chu C. Chinese Sumac (Rhus chinensis Mill.) fruits prevent hyperuricemia and uric acid nephropathy in mice fed a high-purine yeast diet. Nutrients. 2024;16:184.
Hua L, Zhang S, Yang J, Zhou X, Shi S. Sanghuangporus vaninii ethanol extract alleviates hyperuricemic renal injury by regulating the uric acid transporters and inhibiting HK-2 apoptosis. Biomed Pharmacother. 2023;164:114970.
Google Scholar
Wang X, Zhou PJ, Shi HX, Wang WF, Li TT, Tang TT, et al. Essential oil based on NLRP3 inflammasome and renal uric acid transporters for hyperuricemia. Food Biosci. 2023;56:103285.
Sui YL, Xu DP, Sun XL. Identification of anti-hyperuricemic components from Coix seed. Food Biosci. 2023;52:102461.
Wang D, Liu L, Li K, Cao H, Liu M, Chen Q, et al. Eurycoma longifolia alkaloid components ameliorate hyperuricemic nephropathy via regulating serum uric acid level and relieving inflammatory reaction. J Nat Med. 2023;77:867–79.
Google Scholar
Li LZ, Wang XM, Feng XJ, Liu K, Li B, Zhu LJ, et al. Effects of a macroporous Resin extract of Dendrobium officinale leaves in rats with hyperuricemia induced by anthropomorphic unhealthy lifestyle. Evid Based Complement Altern Med. 2023;2023:9990843.
Google Scholar
Wang CC, Li YL, Chiu PY, Chen C, Chen HC, Chen FA. Protective effects of corni fructus extract in mice with potassium oxonate-induced hyperuricemia. J Vet Med Sci. 2022;84:1134–41.
Google Scholar
Luo LS, Wang Y, Dai LJ, He FX, Zhang JL, Zhou Q. Triterpenoid acids from medicinal mushroom Inonotus obliquus (Chaga) alleviate hyperuricemia and inflammation in hyperuricemic mice: Possible inhibitory effects on xanthine oxidase activity. J Food Biochem. 2022;46:e13932.
Google Scholar
Sung YY, Kim DS. Synergistic impacts of Alpinia oxyphylla seed extract and allopurinol against experimental hyperuricemia. Biomed Res Int. 2022;2022:2824535.
Google Scholar
Lee YS, Sung YY, Yuk HJ, Son E, Lee S, Kim JS, et al. Anti-hyperuricemic effect of Alpinia oxyphylla seed extract by enhancing uric acid excretion in the kidney. Phytomedicine. 2019;62:152975.
Google Scholar
Xiang L, Huang YT, Li R, Tao YX, Wu T, Pan SY, et al. Artemisia selengensis Turcz. leaves extract ameliorates hyperuricemia in mice by inhibiting hepatic xanthine oxidase activity, modulating renal uric acid transporters, and improving metabolic disorders. Food Biosci. 2023;56:102639.
Minh TN, Minh BQ, Duc TH, Thinh PV, Anh LV, Dat NT, et al. Potential use of Moringa oleiferatwigs extracts as an anti-hyperuricemic and anti-microbial source. Processes. 2022;10:563.
Abdulhafiz F, Farhan Hanif Reduan M, Hamzah Z, Abdul Kari Z, Dawood MaO, Mohammed A. Acute oral toxicity assessment and anti-hyperuricemic activity of Alocasia longiloba extracts on Sprague-Dawley rats. Saudi J Biol Sci. 2022;29:3184–93.
Google Scholar
Lin S, Meng J, Li F, Yu H, Lin D, Lin S, et al. Ganoderma lucidum polysaccharide peptide alleviates hyperuricemia by regulating adenosine deaminase and urate transporters. Food Funct. 2022;13:12619–31.
Google Scholar
Kim OK, Yun JM, Lee M, Kim D, Lee J. Hypouricemic effects of Chrysanthemum indicum L. and Cornus officinalis on hyperuricemia-induced HepG2 cells, renal cells, and mice. Plants (Basel). 2021;10:1668.
Pan J, Zhang C, Shi M, Guo F, Liu J, Li L, et al. Ethanol extract of Liriodendron chinense (Hemsl.) Sarg barks attenuates hyperuricemic nephropathy by inhibiting renal fibrosis and inflammation in mice. J Ethnopharmacol. 2021;264:113278.
Google Scholar
Kang L, Miao JX, Cao LH, Miao YY, Miao MS, Liu HJ, et al. Total glucosides of herbaceous peony (Paeonia lactiflora Pall.) flower attenuate adenine- and ethambutol-induced hyperuricaemia in rats. J Ethnopharmacol. 2020;261:113054.
Google Scholar
Lou XJ, Wang YZ, Lei SS, He X, Lu TT, Zhan LH, et al. Beneficial effects of macroporous resin extract of Dendrobium candidum leaves in rats with hyperuricemia induced by a high-purine diet. Evid Based Complement Altern Med. 2020;2020:3086106.
Google Scholar
Dang Y, Liang D, Zhou X, Qin Y, Gao Y, Li W. Protective effect of Mori Cortex on kidney in rats with hyperlipidemia and hyperuricemia based on molecular docking technique. Chin Tradit Herb Drugs. 2019;50:1175–81.
Fang C, Chen L, He M, Luo Y, Zhou M, Zhang N, et al. Molecular mechanistic insight into the anti-hyperuricemic effect of Eucommia ulmoides in mice and rats. Pharm Biol. 2019;57:112–9.
Google Scholar
Huang L, Deng J, Chen G, Zhou M, Liang J, Yan B, et al. The anti-hyperuricemic effect of four astilbin stereoisomers in Smilax glabra on hyperuricemic mice. J Ethnopharmacol. 2019;238:111777.
Google Scholar
Liang G, Nie Y, Chang Y, Zeng S, Liang C, Zheng X, et al. Protective effects of Rhizoma smilacis glabrae extracts on potassium oxonate- and monosodium urate-induced hyperuricemia and gout in mice. Phytomedicine. 2019;59:152772.
Google Scholar
Wu XH, Wang CZ, Wang SQ, Mi C, He Y, Zhang J, et al. Anti-hyperuricemia effects of allopurinol are improved by Smilax riparia, a traditional Chinese herbal medicine. J Ethnopharmacol. 2015;162:362–8.
Google Scholar
Ma WG, Wang J, Bu XW, Zhang HH, Zhang JP, Zhang XX, et al. Effects of Polygonum cuspidatum on AMPK-FOXO3alpha signaling pathway in rat model of uric acid-induced renal damage. Chin J Integr Med. 2019;25:182–9.
Google Scholar
Hu QQ, Ji J, Xu DP, Ye YL, Sun JD, Sheng LA, et al. Isolation and characterization of uric acid-lowering functional components from Polygonum cuspidatum. Food Biosci. 2023;53:102314.
Peng A, Lin L, Zhao M, Sun B. Identifying mechanisms underlying the amelioration effect of Chrysanthemum morifolium Ramat. ‘Boju’ extract on hyperuricemia using biochemical characterization and UPLC-ESI-QTOF/MS-based metabolomics. Food Funct. 2019;10:8042–55.
Google Scholar
Yang LX, Xue JJ, Meng XY, Wang YS, Wu LL, Lv CY, et al. Effects of total flavonoids from Oxytropis falcata Bunge on the SOCS/JAK/STAT inflammatory signaling pathway in the kidneys of diabetic nephropathy model mice. Eur J Inflamm. 2019;17:2058739219861877.
Lee YS, Kim SH, Yuk HJ, Kim DS. DKB114, a mixture of Chrysanthemum Indicum Linne flower and Cinnamomum Cassia (L.) J. Presl Bark extracts, improves hyperuricemia through inhibition of xanthine oxidase activity and increasing urine excretion. Nutrients. 2018;10:1381.
Wang Y, Zhao M, Xin Y, Liu J, Wang M, Zhao C. (1)H NMR and MS based metabolomics study of the therapeutic effect of Cortex Fraxini on hyperuricemic rats. J Ethnopharmacol. 2016;185:272–81.
Google Scholar
Zhou Y, Zhang X, Li C, Yuan X, Han L, Li Z, et al. Research on the pharmacodynamics and mechanism of Fraxini Cortex on hyperuricemia based on the regulation of URAT1 and GLUT9. Biomed Pharmacother. 2018;106:434–42.
Google Scholar
Song SH, Park DH, Bae MS, Choi CY, Shim JH, Yoon G, et al. Ethanol extract of Cudrania tricuspidata leaf ameliorates hyperuricemia in mice via inhibition of hepatic and serum xanthine oxidase activity. Evid Based Complement Altern Med. 2018;2018:8037925.
Google Scholar
Xiong W, Zhang H, Wen L, Wang X, Zhong G, Shi Y, et al. Effect of Lagotis brachystachys Maxim extract on xanthine oxidase and renal urate transporters in hyperuricemia mice. Chin J New Drugs. 2018;27:1538–43.
Yong T, Chen S, Xie Y, Chen D, Su J, Shuai O, et al. Hypouricemic effects of Ganoderma applanatum in hyperuricemia mice through OAT1 and GLUT9. Front Pharmacol. 2017;8:996.
Google Scholar
Zhang R, Zhan S, Li S, Zhu Z, He J, Lorenzo JM, et al. Anti-hyperuricemic and nephroprotective effects of extracts from Chaenomeles sinensis (Thouin) Koehne in hyperuricemic mice. Food Funct. 2018;9:5778–90.
Google Scholar
Chen W, Wu Y, Bi R, Liu S, Liu Z, Liu Z, et al. Therapeutic effects of Selaginella tamariscina on the model of acute gout with hyperuricemia in rats based on metabolomics analysis. Chin J Chem. 2017;35:1117–24.
Google Scholar
Chen W, Liu Y, Wei M, Shi L, Wu Y, Liu Z, et al. Studies on effect of Ginkgo biloba L. leaves in acute gout with hyperuricemia model rats by using UPLC-ESI-Q-TOF/MS metabolomic approach. Rsc Adv. 2017;7:42964–72.
Google Scholar
Kim JK, Kim WJ, Hyun JM, Lee JS, Kwon JG, Seo C, et al. Salvia plebeia extract inhibits xanthine oxidase activity in vitro and reduces serum uric acid in an animal model of hyperuricemia. Planta Med. 2017;83:1335–41.
Google Scholar
Li YP, Wu S, Ran A, Xu DY, Wei JM, Zhao ZL. Aristolochia Bracteolate Retz. attenuates hyperuricemia in a metabolic arthritis rat model. Afr J Tradit Complement Alter Med. 2017;14:180–7.
Google Scholar
Xia N, Li BA, Liu HJ, Fan JB, Shen W, He XG. Anti-hyperuricemic effect of Plantago depressa Willd extract in rats. Trop J Pharmacol Res. 2017;16:1365–8.
Google Scholar
Yoon IS, Park DH, Bae MS, Oh DS, Kwon NH, Kim JE, et al. In vitro and in vivo studies on Quercus acuta Thunb. (Fagaceae) extract: active constituents, serum uric acid suppression, and xanthine oxidase inhibitory activity. Evid Based Complement Altern Med. 2017;2017:4097195.
Google Scholar
Yoon IS, Park DH, Kim JE, Yoo JC, Bae MS, Oh DS, et al. Identification of the biologically active constituents of Camellia japonica leaf and anti-hyperuricemic effect in vitro and in vivo. Int J Mol Med. 2017;39:1613–20.
Google Scholar
Zhu L, Dong Y, Na S, Han R, Wei C, Chen G. Saponins extracted from Dioscorea collettii rhizomes regulate the expression of urate transporters in chronic hyperuricemia rats. Biomed Pharmacother. 2017;93:88–94.
Google Scholar
Gao H, Liu Z, Song F, Xing J, Zheng Z, Hou Z, et al. Establishment of polydopamine-modified HK-2 cell membrane chromatography and screening of active components from Plantago asiatica L. Int J Mol Sci. 2024;25:1153.
Hou SW, Chen SJ, Shen JD, Chen HY, Wang SJ, Wang CH, et al. Emodin, a natural anthraquinone, increases uric acid excretion in rats with potassium oxonate-induced hyperuricemia. Pharmaceuticals (Basel). 2023;16:789.
Huang KC, Chang YT, Pranata R, Cheng YH, Chen YC, Kuo PC, et al. Alleviation of hyperuricemia by strictinin in AML12 mouse hepatocytes treated with xanthine and in mice treated with potassium oxonate. Biology (Basel). 2023;12:329.
Chen J, Zheng Y, Gong S, Zheng Z, Hu J, Ma L, et al. Mechanisms of theaflavins against gout and strategies for improving the bioavailability. Phytomedicine. 2023;114:154782.
Google Scholar
Guo XL, Gao YY, Yang YX, Zhu QF, Guan HY, He X, et al. Amelioration effects of alpha-viniferin on hyperuricemia and hyperuricemia-induced kidney injury in mice. Phytomedicine. 2023;116:154868.
Google Scholar
Wang H, Zhang H, Zhang X, Yin Y, Ding G, Tang X, et al. Identification of coniferyl ferulate as the bioactive compound behind the xanthine oxidase inhibitory activity of Chuanxiong Rhizome. J Funct Foods. 2023;100:105378.
Dai H, Xu X, Li W, Fu X, Han W, Li G. Investigating the vital role of the identified abietic acid from Helianthus annuus L. Calathide extract against hyperuricemia via human embryonic kidney 293T cell model. Molecules. 2023;28:5141.
Niu Y, Li Q, Tu C, Li N, Gao L, Lin H, et al. Hypouricemic actions of the pericarp of Mangosteen in vitro and in vivo. J Nat Prod. 2023;86:24–33.
Google Scholar
Zhong L, Lin Y, Gong S, Wu X, Liu Y, Chen J, et al. Oxyberberrubine, a novel liver microsomes-mediated secondary metabolite of berberine, alleviates hyperuricemic nephropathy in mice. Phytomedicine. 2023;108:154521.
Google Scholar
Li Q, Lin H, Niu Y, Liu Y, Wang Z, Song L, et al. Mangiferin promotes intestinal elimination of uric acid by modulating intestinal transporters. Eur J Pharmacol. 2020;888:173490.
Google Scholar
Riaz M, Al Kury LT, Atzaz N, Alattar A, Alshaman R, Shah FA, et al. Carvacrol alleviates hyperuricemia-induced oxidative stress and inflammation by modulating the NLRP3/NF-kappaB pathway. Drug Des Devel Ther. 2022;16:1159–70.
Google Scholar
Wang F, Zhao X, Su X, Song D, Zou F, Fang L. Isorhamnetin, the xanthine oxidase inhibitor from Sophora japonica, ameliorates uric acid levels and renal function in hyperuricemic mice. Food Funct. 2021;12:12503–12.
Google Scholar
Zhang D, Zhao M, Li Y, Zhang D, Yang Y, Li L. Natural xanthine oxidase inhibitor 5-O-Caffeoylshikimic acid ameliorates kidney injury caused by hyperuricemia in mice. Molecules. 2021;26:7307.
Wu J, Luo Y, Jiang Q, Li S, Huang W, Xiang L, et al. Coptisine from Coptis chinensis blocks NLRP3 inflammasome activation by inhibiting caspase-1. Pharmacol Res. 2019;147:104348.
Google Scholar
Vijeesh V, Vysakh A, Jisha N, Latha MS. In vitro enzyme inhibition and in vivo anti-hyperuricemic potential of eugenol: an experimental approach. Drug Dev Ind Pharmacol. 2021;47:1998–2003.
Google Scholar
Liu T, Gao H, Zhang Y, Wang S, Lu M, Dai X, et al. Apigenin ameliorates hyperuricemia and renal injury through regulation of uric acid metabolism and JAK2/STAT3 signaling pathway. Pharmaceuticals (Basel). 2023;16:819. Corrected and republished from: Mol Cell Endocrinol. 2022;15:1442.
Xiao B, Ma W, Zheng Y, Li Z, Li D, Zhang Y, et al. Effects of resveratrol on the inflammatory response and renal injury in hyperuricemic rats. Nutr Res Pr. 2021;15:26–37.
Google Scholar
Zhang X, Nie Q, Zhang Z, Zhao J, Zhang F, Wang C, et al. Resveratrol affects the expression of uric acid transporter by improving inflammation. Mol Med Rep. 2021;24:564.
Li L, Li Y, Luo J, Jiang Y, Zhao Z, Chen Y, et al. Resveratrol, a novel inhibitor of GLUT9, ameliorates liver and kidney injuries in a D-galactose-induced ageing mouse model via the regulation of uric acid metabolism. Food Funct. 2021;12:8274–87.
Google Scholar
Zhou X, Zhang B, Zhao X, Lin Y, Wang J, Wang X, et al. Chlorogenic acid supplementation ameliorates hyperuricemia, relieves renal inflammation, and modulates intestinal homeostasis. Food Funct. 2021;12:5637–49.
Google Scholar
Nihei T, Ushiro E, Sato H, Onoue S. Biopharmaceutical study on nobiletin-loaded amorphous solid dispersion with improved hypouricemic effect. Molecules. 2021;26:4447.
Chang YH, Chiang YF, Chen HY, Huang YJ, Wang KL, Hong YH, et al. Anti-inflammatory and anti-hyperuricemic effects of chrysin on a high fructose corn syrup-induced hyperuricemia rat model via the amelioration of urate transporters and inhibition of NLRP3 inflammasome signaling pathway. Antioxidants (Basel). 2021;10:564.
Zhu C, Xu Y, Liu ZH, Wan XC, Li DX, Tai LL. The anti-hyperuricemic effect of epigallocatechin-3-gallate (EGCG) on hyperuricemic mice. Biomed Pharmacother. 2018;97:168–73.
Google Scholar
Bi WY, Zhu CL. Genistein ameliorates hyperuricemia-associated nephropathy in hyperuricemic mice. Food Agric Immunol. 2021;32:778–97.
Google Scholar
Chen M, Ye C, Zhu J, Zhang P, Jiang Y, Lu X, et al. Bergenin as a novel urate-lowering therapeutic strategy for hyperuricemia. Front Cell Dev Biol. 2020;8:703.
Google Scholar
An MF, Wang MY, Shen C, Sun ZR, Zhao YL, Wang XJ, et al. Isoorientin exerts a urate-lowering effect through inhibition of xanthine oxidase and regulation of the TLR4-NLRP3 inflammasome signaling pathway. J Nat Med. 2021;75:129–41.
Google Scholar
Afify H, Abo-Youssef AM, Abdel-Rahman HM, Allam S, Azouz AA. The modulatory effects of cinnamaldehyde on uric acid level and IL-6/JAK1/STAT3 signaling as a promising therapeutic strategy against benign prostatic hyperplasia. Toxicol Appl Pharmacol. 2020;402:115122.
Google Scholar
Li G, Guan C, Xu L, Wang L, Yang C, Zhao L, et al. Scutellarin ameliorates renal injury via increasing CCN1 expression and suppressing NLRP3 inflammasome activation in hyperuricemic mice. Front Pharmacol. 2020;11:584942.
Google Scholar
Wang Y, Kong W, Wang L, Zhang T, Huang B, Meng J, et al. Multiple-purpose connectivity map analysis reveals the benefits of esculetin to hyperuricemia and renal fibrosis. Int J Mol Sci. 2020;21:7695.
Cui D, Liu S, Tang M, Lu Y, Zhao M, Mao R, et al. Phloretin ameliorates hyperuricemia-induced chronic renal dysfunction through inhibiting NLRP3 inflammasome and uric acid reabsorption. Phytomedicine. 2020;66:153111.
Google Scholar
Weng W, Wang Q, Wei C, Man N, Zhang K, Wei Q, et al. Preparation, characterization, pharmacokinetics and anti-hyperuricemia activity studies of myricitrin-loaded proliposomes. Int J Pharm. 2019;572:118735.
Google Scholar
Liu X, Zhao Y, Zhou Y, Huang M, Huang S, Zhen H, et al. Anti-gout effect of hirudin and its mechanism. Chin Tradit Herb Drugs. 2018;49:1365–70.
Wang Q, Yang Q, Cao X, Wei Q, Firempong CK, Guo M, et al. Enhanced oral bioavailability and anti-gout activity of [6]-shogaol-loaded solid lipid nanoparticles. Int J Pharm. 2018;550:24–34.
Google Scholar
Zhang Y, Jin L, Liu J, Wang W, Yu H, Li J, et al. Effect and mechanism of dioscin from Dioscorea spongiosa on uric acid excretion in animal model of hyperuricemia. J Ethnopharmacol. 2018;214:29–36.
Google Scholar
Yong T, Chen S, Xie Y, Chen D, Su J, Shuai O, et al. Cordycepin, a characteristic bioactive constituent in Cordyceps militaris, ameliorates hyperuricemia through URAT1 in hyperuricemic mice. Front Microbiol. 2018;9:58.
Google Scholar
Chen YS, Chen CJ, Yan W, Ge HM, Kong LD. Anti-hyperuricemic and anti-inflammatory actions of vaticaffinol isolated from Dipterocarpus alatus in hyperuricemic mice. Chin J Nat Med. 2017;15:330–40.
Google Scholar
Pang M, Fang Y, Chen S, Zhu X, Shan C, Su J, et al. Gypenosides inhibits xanthine oxidoreductase and ameliorates urate excretion in hyperuricemic rats induced by high cholesterol and high fat food (lipid emulsion). Med Sci Monit. 2017;23:1129–40.
Google Scholar
Wang Y, Zhao M, Ye H, Shao Y, Yu Y, Wang M, et al. Comparative pharmacokinetic study of the main components of cortex fraxini after oral administration in normal and hyperuricemic rats. Biomed Chromatogr. 2017;31. https://doi.org/10.1002/bmc.3934.
Zhang C, Zhang G, Liao Y, Gong D. Myricetin inhibits the generation of superoxide anion by reduced form of xanthine oxidase. Food Chem. 2017;221:1569–77.
Google Scholar
Meng X, Mao Z, Li X, Zhong D, Li M, Jia Y, et al. Baicalein decreases uric acid and prevents hyperuricemic nephropathy in mice. Oncotarget. 2017;8:40305–17.
Google Scholar
Hongyan L, Suling W, Weina Z, Yajie Z, Jie R. Antihyperuricemic effect of liquiritigenin in potassium oxonate-induced hyperuricemic rats. Biomed Pharmacother. 2016;84:1930–6.
Google Scholar
Wang Y, Zhang G, Pan J, Gong D. Novel insights into the inhibitory mechanism of kaempferol on xanthine oxidase. J Agric Food Chem. 2015;63:526–34.
Google Scholar
Hou PY, Mi C, He Y, Zhang J, Wang SQ, Yu F, et al. Pallidifloside D from Smilax riparia enhanced allopurinol effects in hyperuricemia mice. Fitoterapia. 2015;105:43–48.
Google Scholar
Xing ZH, Ma YC, Li XP, Zhang B, Zhang MD. Research progress of puerarin and its derivatives on anti-inflammatory and anti-gout activities. Zhongguo Zhong Yao Za Zhi. 2017;42:3703–8.
Bai L, Wu C, Lei S, Zou M, Wang S, Zhang Z, et al. Potential anti-gout properties of Wuwei Shexiang pills based on network pharmacology and pharmacological verification. J Ethnopharmacol. 2023;305:116147.
Google Scholar
Wu ZC, Xue Q, Zhao ZL, Zhou PJ, Zhou Q, Zhang Z, et al. Suppressive effect of Huzhentongfeng on experimental gouty arthritis: an in vivo and in vitro study. Evid Based Complement Altern Med. 2019;2019:2969364.
Google Scholar
Han J, Xie Y, Sui F, Liu C, Du X, Liu C, et al. Zisheng Shenqi decoction ameliorates monosodium urate crystal-induced gouty arthritis in rats through anti-inflammatory and anti-oxidative effects. Mol Med Rep. 2016;14:2589–97.
Google Scholar
Li WH, Han JR, Ren PP, Xie Y, Jiang DY. Exploration of the mechanism of Zisheng Shenqi decoction against gout arthritis using network pharmacology. Comput Biol Chem. 2021;90:107358.
Google Scholar
Kou Y, Li Y, Ma H, Li W, Li R, Dang Z. Uric acid lowering effect of Tibetan Medicine RuPeng15 powder in animal models of hyperuricemia. J Tradit Chin Med. 2016;36:205–10.
Google Scholar
Kou YY, Li YF, Xu M, Li WY, Yang M, Li RL. Effects of RuPeng15 Powder (RPP15) on monosodium urate crystal-induced gouty arthritis in rats. Evid Based Complement Altern Med. 2015;2015:527019.
Google Scholar
Kodithuwakku ND, Feng YD, Zhang YY, Pan M, Fang WR, Li YM. The molecular insight into the antihyperuricemic and renoprotective effect of Shuang Qi gout capsule in mice. J Ethnopharmacol. 2015;163:278–89.
Google Scholar
Kodithuwakku ND, Pan M, Zhu YL, Zhang YY, Feng YD, Fang WR, et al. Anti-inflammatory and antinociceptive effects of Chinese medicine SQ gout capsules and its modulation of pro-inflammatory cytokines focusing on gout arthritis. J Ethnopharmacol. 2013;150:1071–9.
Google Scholar
Wang H, Chen ST, Ding XJ, Kuai L, Hua L, Li X, et al. Efficacy and safety of Huzhang Granule, a compound Chinese herbal medicine, for acute gouty arthritis: a double-blind, randomized controlled trial. J Integr Med. 2024;22:270–8.
Google Scholar
Ren S, Meng F, Liu Y, Meng Y, Tao N, Liu R, et al. Effects of external application of compound Qingbi granules on acute gouty arthritis with dampness-heat syndrome: a randomized controlled trial. Chin Med. 2020;15:117.
Google Scholar
Yang BL, Ding G. Observation of Qigui Tongfengshu granules in treatment of sixteen cases of gouty arthritis. Zhongguo Zhong Yao Za Zhi. 2013;38:276–7.
Google Scholar
Dong L, Zhang S, Chen L, Lu J, Zhao F, Long T, et al. In vivo anti-hyperuricemia and anti-gouty arthritis effects of the ethanol extract from Amomumvillosum Lour. Biomed Pharmacother. 2023;161:114532.
Google Scholar
Qian X, Jiang Y, Luo Y, Jiang Y. The anti-hyperuricemia and anti-inflammatory effects of Atractylodes Macrocephala in hyperuricemia and gouty arthritis rat models. Comb Chem High Throughput Screen. 2023;26:950–64.
Google Scholar
Chen WD, Zhao YL, Sun WJ, He YJ, Liu YP, Jin Q, et al. “Kidney Tea” and its bioactive secondary metabolites for treatment of gout. J Agric Food Chem. 2020;68:9131–8.
Google Scholar
Chen Y, Pei C, Chen Y, Xiao X, Zhang X, Cai K, et al. Kidney tea ameliorates hyperuricemia in mice via altering gut microbiota and restoring metabolic profile. Chem Biol Interact. 2023;376:110449.
Google Scholar
Zhou X, Shi Q, Li J, Quan S, Zhang X, Gu L, et al. Medicinal fungus Phellinus igniarius alleviates gout in vitro by modulating TLR4/NF-kappaB/NLRP3 signaling. Front Pharmacol. 2022;13:1011406.
Google Scholar
Lee J, Hong SM, Park N, Lee J, Jang SG, Cho ML, et al. Red ginseng extracts as an adjunctive therapeutic for gout: preclinical and clinical evidence. Food Agric Immunol. 2021;32:1–14.
Google Scholar
Yao R, Geng Z, Mao X, Bao Y, Guo S, Bao L, et al. Tu-Teng-Cao extract alleviates monosodium urate-induced acute gouty arthritis in rats by inhibiting uric acid and inflammation. Evid Based Complement Altern Med. 2020;2020:3095624.
Google Scholar
Li S, Li L, Yan H, Jiang X, Hu W, Han N, et al. Anti‑gouty arthritis and anti‑hyperuricemia properties of celery seed extracts in rodent models. Mol Med Rep. 2019;20:4623–33.
Google Scholar
Wang X, Zhang Y, Zhang M, Kong H, Wang S, Cheng J, et al. Novel carbon dots derived from Puerariae lobatae Radix and their anti-gout effects. Molecules. 2019;24:4152.
Wang Y, Lin Z, Zhang B, Jiang Z, Guo F, Yang T. Cichorium intybus L. extract suppresses experimental gout by inhibiting the NF-kappaB and NLRP3 signaling pathways. Int J Mol Sci. 2019;20:4921.
Yang B, Huang J, Meng Q, Yuan W, Liang X. Effects of ethanol extract from Gentiana macrophylla on oxidative stress injury and miR-34a/sirt1 Axis in rats with gouty arthritis. Pharmacol Clin Chin Mater Med. 2019;35:64–69.
Zhang HJ, Li LN, Zhou J, Yang QQ, Liu PG, Xu P, et al. Effects of Gnaphalium affine D. Don on hyperuricemia and acute gouty arthritis. J Ethnopharmacol. 2017;203:304–11.
Google Scholar
Liu HJ, Pan XX, Liu BQ, Gui X, Hu L, Jiang CY, et al. Grape seed-derived procyanidins alleviate gout pain via NLRP3 inflammasome suppression. J Neuroinflammation. 2017;14:74.
Google Scholar
Li L, Teng M, Liu Y, Qu Y, Zhang Y, Lin F, et al. Anti-gouty arthritis and antihyperuricemia effects of Sunflower (Helianthus annuus) Head extract in gouty and hyperuricemia animal models. Biomed Res Int. 2017;2017:5852076.
Google Scholar
Dai H, Lv S, Qiao Z, Wang K, Zhou X, Bao C, et al. The active components of Sunflower (Helianthus annuus L.) Calathide and the effects on urate nephropathy based on COX-2/PGE2 signaling pathway and the urate transporter URAT1, ABCG2, and GLUT9. Front Nutr. 2021;8:769555.
Google Scholar
Chen L, Mola M, Deng X, Mei Z, Huang X, Shu G, et al. Dolichos falcata Klein attenuated the inflammation induced by monosodium urate crystals in vivo and in vitro. J Ethnopharmacol. 2013;150:545–52.
Google Scholar
Jiang Y, You XY, Fu KL, Yin WL. Effects of extract from Mangifera indica leaf on monosodium urate crystal-induced gouty arthritis in rats. Evid Based Complement Altern Med. 2012;2012:967573.
Google Scholar
Park H, Ko R, Seo J, Ahn GY, Choi SW, Kwon M, et al. Octyl gallate has potent anti-inflammasome activity by directly binding to NLRP3 LRR domain. J Cell Physiol. 2024;239:e31196.
Google Scholar
Zhou X, Qin M, He L, Zhang Y, Liu A, Chen D, et al. Geraniin restricts inflammasome activation and macrophage pyroptosis by preventing the interaction between ASC and NLRP3 to exert anti-inflammatory effects. Int Immunopharmacol. 2024;129:111656.
Google Scholar
Dang WT, Xu D, Zhou JG. Effect of berberine on activation of TLR4-NFkappaB signaling pathway and NLRP3 inflammasome in patients with gout. Chin J Integr Med. 2023;29:10–18.
Google Scholar
Xu WJ, Chen YF, Li FF, Zhang XX, Li CT, Wu CX, et al. Polydatin alleviates hyperuricemia combined with gouty arthritis in mice via regulating urate transporters, NLRP3 inflammasome and NF-κB pathway. J Funct Foods. 2023;105:105582.
Tumova S, Shi Y, Carr IM, Williamson G. Effects of quercetin and metabolites on uric acid biosynthesis and consequences for gene expression in the endothelium. Free Radic Biol Med. 2021;162:191–201.
Google Scholar
De Oliveira DP, Garcia EF, De Oliveira MA, Candido LCM, Coelho FM, Costa VV, et al. cis-Aconitic acid, a constituent of Echinodorus grandiflorus leaves, inhibits antigen-induced arthritis and gout in mice. Planta Med. 2022;88:1123–31.
Google Scholar
Lo CW, Lii CK, Hong JJ, Chuang WT, Yang YC, Huang CS, et al. Andrographolide inhibits IL-1beta release in bone marrow-derived macrophages and monocyte infiltration in mouse knee joints induced by monosodium urate. Toxicol Appl Pharmacol. 2021;410:115341.
Google Scholar
Chen G, Jia P, Yin ZY, Kong SZ, Xiang ZB, Zheng XX. Paeonol ameliorates monosodium urate-induced arthritis in rats through inhibiting nuclear factor-kappaB-mediated proinflammatory cytokine production. Phytother Res. 2019;33:2971–8.
Google Scholar
Chen G, Guo T, Yang L. Paeonol reduces IL-beta production by inhibiting the activation of nucleotide oligomerization domain-like receptor protein-3 inflammasome and nuclear factor-kappaB in macrophages. Biochem Cell Biol. 2022;100:28–36.
Google Scholar
Lodhi S, Vadnere GP, Patil KD, Patil TP. Protective effects of luteolin on injury induced inflammation through reduction of tissue uric acid and pro-inflammatory cytokines in rats. J Tradit Complement Med. 2020;10:60–9.
Google Scholar
Kim HB, Kwon SC, Sun X, Akther M, Han JH, Kim TY, et al. Vanillylacetone attenuates NLRP3 inflammasome mediated immune responses in murine bone marrow derived macrophages via NLRP3 alkylation. J Funct Foods. 2020;64:103655.
Jiang L, Wu Y, Qu C, Lin Y, Yi X, Gao C, et al. Hypouricemic effect of gallic acid, a bioactive compound from Sonneratia apetala leaves and branches, on hyperuricemic mice. Food Funct. 2022;13:10275–90.
Google Scholar
Chang WC, Chu MT, Hsu CY, Wu YJ, Lee JY, Chen TJ, et al. Rhein, an anthraquinone drug, suppresses the NLRP3 inflammasome and macrophage activation in urate crystal-induced gouty inflammation. Am J Chin Med. 2019;47:135–51.
Google Scholar
Lyu S, Ding R, Liu P, Ouyang H, Feng Y, Rao Y, et al. LC-MS Analysis of serum for the metabolomic investigation of the effects of pulchinenoside b4 administration in monosodium urate crystal-induced gouty arthritis rat model. Molecules. 2019;24:3161.
Yang TH, Yan DX, Huang XY, Hou B, Ma YB, Peng H, et al. Termipaniculatones A-F, chalcone-flavonone heterodimers from Terminthia paniculata, and their protective effects on hyperuricemia and acute gouty arthritis. Phytochemistry. 2019;164:228–35.
Google Scholar
Dhanasekar C, Rasool M. Morin, a dietary bioflavonol suppresses monosodium urate crystal-induced inflammation in an animal model of acute gouty arthritis with reference to NLRP3 inflammasome, hypo-xanthine phospho-ribosyl transferase, and inflammatory mediators. Eur J Pharmacol. 2016;786:116–27.
Google Scholar
Wei H, Hu C, Xie J, Yang C, Zhao Y, Guo Y, et al. Doliroside A attenuates monosodium urate crystals-induced inflammation by targeting NLRP3 inflammasome. Eur J Pharmacol. 2014;740:321–8.
Google Scholar
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